Archive - Bits of Bio

MiSeq and NextSeq Glass Compared.

Yesterday I posted some notes on the NextSeq 550 flowcell and noted my confusion about the glass used in the NextSeq 550.

Mar 1 •

February 2024

Quick Thoughts On Illumina Insert Size Limits

We were chatting about insert size limits in Illumina sequencing on the Discord today.

Feb 29 •

In order to evaluate Illumina Complete Long Reads (CLR), I thought it might be interesting to compare them to PacBio Continuous Long Reads (CLR). So, in…

Feb 28 •

January 2024

The BioSecure Act "Anti-BGI" Bill

There’s a bill that’s been proposed to the US house of representatives.

Jan 30 •

NextSeq 550 XY Stage Notes

I decided to have a quick play with the NextSeq 550 XY Stage.

Jan 10 •

The NextSeq 2000

I’m putting together a post on Illumina’s current instrument lineup for the other substack.

Jan 9 •

JPM Talking Points

With the JPM Healthcare Conference kicking off today, I thought the following quote might prompt discussion.

Jan 8 •

December 2023

Your Ears Are Small So No Diagnostics For You...

Summary: There seems to be a broad consensus that you can’t identify or screen for Fragile X (a leading cause of intellectual disability) on the basis…

Dec 9, 2023 •

[Some] Doctors Don't Like Running Tests

Summary: Some doctors don’t like running tests if they don’t that think it will result in a change in patient management or direct changes in patient…

Dec 7, 2023 •

November 2023

Undiagnosed Pneumonia...

I like to keep an eye on the ProMed mailing list.

Nov 23, 2023 •

Platform Benchmarks Workflow

Recently I’ve been running a bunch of sequencing datasets though BEST to generate some basic run statistics.

Nov 22, 2023 •

The Solexa Acquisition and Anti-Takeover

A few folks objected to my recent post on the other stack.

Nov 17, 2023 •

#nojs-banner { position: fixed; bottom: 0; left: 0; padding: 16px 16px 16px 32px; width: 100%; box-sizing: border-box; background: red; color: white; font-family: -apple-system, "Segoe UI", Roboto, Helvetica, Arial, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol"; font-size: 13px; line-height: 13px; } #nojs-banner a { color: inherit; text-decoration: underline; } This site requires JavaScript to run correctly. Please turn on JavaScript or unblock scripts